Publications

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Showing posts with label mhc. Show all posts
Showing posts with label mhc. Show all posts
Wednesday, February 28, 2024

p53 Convergence and Immunity

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Renewed interest in  Bradykinin  and its inactivation, by Angiotensin Converting Enzyme (ACE),  during Covid infection  reconfirmed RAS and ...
Sunday, January 28, 2024

All Roads Lead to (Ch)Romosome 19!

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A hepatocellular carcinoma (HCC)  co-regulatory network  exists between chromosome 19 microRNA cluster (C19MC) at 19q13.42, melanoma-A antig...
Monday, January 1, 2024

p53 - Mediator Of Natural Killer Education

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The regulation of rapidly transforming stem cells into trophoblasts and expanding embryonic cell phenotypes, between gestation day 8 and 15 ...
Tuesday, October 10, 2023

Cancer's HLA-G Backdoor

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piRNA actively control transposable elements (TE) that would otherwise disrupt genes, chromosomal stability, damage DNA, cause inflammation,...
Wednesday, September 27, 2023

When Immunity Fails Programmed Cell Death

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DNA Damage Response Telomeric repeat (TR) sequences are responsible for genome integrity, where instability is a primary factor that leads ...
Wednesday, May 17, 2023

Immune Synchronization

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Stem Cell Navigating the regulatory regimes that govern drug safety can be challenging. But, rigorous standards are more relaxed in the less...
Thursday, October 20, 2022

Toward Customized Natural Killer Cells

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An important role of Natural Killer (NK) cells is to eliminate other cells that extinguish or diminish expression of self-MHC class I molec...
Thursday, February 3, 2022

Expanding Treatment Horizons

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An unrecognized link between  p53 function and the immunosurveillance of cancer and infection  led to an understanding how p53 influences th...
Sunday, January 16, 2022

Evidence of Purposeful Evolution

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Darwin's evolution challenged! A recently published article in Nautre challenged evolution theory suggesting DNA repair was the more li...
Thursday, April 22, 2021

IFN-γ Concentration, p53 and Immune Sensitivity

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IFN-γ  Dimorphic complexity between Human Leukocyte Antigen (HLA) and Killer Immune Receptor (KIR) haplotypes introduce significant challeng...
Monday, March 8, 2021

Custom Immunotherapy To Address Dimorphic Complexities.

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Dimorphic relationships between genes on Chromosome (Chr)6, encoding Human Leukocyte Antigens (HLA) and those on Chr19, encoding Killer-cell...
Monday, December 28, 2020

Natural Killers at the Neuro-Immune Axis!

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Much has been said about the role Natural Killer (NK) cells play in positively and negatively influencing events in tissues and cells. Summa...
Monday, November 2, 2020

An Integrated P53 Puzzle - Glycolysis in Cancer, Diabetes and Immunity!

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Oxygen poor, hypoxic tissue promotes a cellular shift in mitochondrial metabolism from OXPHOS to less energy efficient glycolysis. Each shif...
Sunday, September 6, 2020

p53 in the SARS-CoV2 Storm

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Coronavrius induced cytokine storm A massive simulation and analysis using the supercomputer at Oakridge led scientists to more accurately i...
Monday, May 11, 2020

Blood Pressure by Natural Killer Cells and SARS-CoV2

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A meta-analysis of gene expression signatures  for diastolic, systolic blood pressure and hypertension found that out of 7717 unique, relate...