Publications

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Showing posts with label t-cell. Show all posts
Showing posts with label t-cell. Show all posts
Wednesday, February 19, 2025

P53 - Stability and Life Or Disorder and Death!

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Chromosomal stability is central to good health, but the push and shove war of genesis, division, transcription, replication and restraint c...
Thursday, April 22, 2021

IFN-γ Concentration, p53 and Immune Sensitivity

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IFN-γ  Dimorphic complexity between Human Leukocyte Antigen (HLA) and Killer Immune Receptor (KIR) haplotypes introduce significant challeng...
Monday, March 8, 2021

Custom Immunotherapy To Address Dimorphic Complexities.

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Dimorphic relationships between genes on Chromosome (Chr)6, encoding Human Leukocyte Antigens (HLA) and those on Chr19, encoding Killer-cell...
Sunday, December 13, 2020

Natural Killers Linked to Overall Survival in Cancer

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A meta analysis of tumor samples, collected between 1973 and 2016, in 53 studies confirmed overall survival (OS) correlated with Natural Kil...
Monday, November 2, 2020

An Integrated P53 Puzzle - Glycolysis in Cancer, Diabetes and Immunity!

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Oxygen poor, hypoxic tissue promotes a cellular shift in mitochondrial metabolism from OXPHOS to less energy efficient glycolysis. Each shif...
Tuesday, October 20, 2020

p53 in Transition, Covid19, Cancer and Immunity

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p53's trajectory, sensitivity and function influences different outcomes in stages of transition of developing pluripotent or embryonic ...
Monday, May 11, 2020

Blood Pressure by Natural Killer Cells and SARS-CoV2

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A meta-analysis of gene expression signatures  for diastolic, systolic blood pressure and hypertension found that out of 7717 unique, relate...
Wednesday, May 6, 2020

Is The Natural Killer our Anti-Cell?

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Lymphocyte Natural Killer (NK) cells may be our innate, anti-cell sentinels that first arise in the yolk sac between day 8 and 10 . Simu...
Sunday, April 5, 2020

What does COVID-19 have to do with heart attack?

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Ground Glass Opacity's in Lungs N atural Killer (NK) cells are depleted, but neutrophils are elevated in the lungs of hospitalized C...
Wednesday, March 25, 2020

Natural Killer to Kill or Transform?

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Natural Killer cells emerge from distinct sources in embryonic development and each source of these earliest, innate immune cells confers d...
Monday, November 25, 2019

Synapses By p53 And CD40L in Reproduction and Immunity

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Cell membranes constitute a diverse range of lipid molecules each attached to a varying, odd or even length hydrocarbon chain (a tail) tha...
Saturday, September 28, 2019

A p53 Checkpoint For Cancer Therapy

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Enormously complex signaling exists in the communication of antigens, receptors and ligands in DNA pathways between Natural Killer cell...
Wednesday, September 4, 2019

Hope for a p53 Autologous Natural Killer Cell Therapy

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Natural Killer Cells (NK) are much more than cell killers! They possess mechanisms and sensitivities that, among many functions, enables...
Tuesday, July 16, 2019

Natural Killer Shaping A Life

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As explained in previous posts , reproduction and innate immunity conspire when maternal Natural Killer (NK) cells of the decidua, lining th...